EFFECTS OF 10-METHOXYDESERPIDINE ON THE ECG CHANGES INDUCED BY VASOPRESSIN IN UNANESTHETIZED RABBIT
Open Access
- 1 January 1965
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 15 (1) , 30-40
- https://doi.org/10.1254/jjp.15.30
Abstract
The effects of 10-methoxydeserpidine on the ECG [electrocardiogram] changes produced by vasopressin (1.0 U/kg intravenously) were studied in unanesthetized but restrained rabbits. 10-Methoxy-deserpidine reduced the occurrence of ventricular extrasystole but promoted the manifestation of sinus arrhythmia and sinus bradycardia. The increase in height of T wave and the elevation of ST level following vasopressin were markedly reduced in occurrence and extent. The ST depression and the flattening of T wave, sometimes followed the ST elevation and the T increase, were abolished.Keywords
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