EFFECT OF LONG-TERM ADMINISTRATION OF DESICCATED THYROID ON SERUM LIPOPROTEIN AND CHOLESTEROL LEVELS*†

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Abstract
IN A previous publication (1) it was shown that the concentration of certain of the low-density serum lipoproteins, i.e., the Standard SfO–12 and Standard Sfl2–20 lipoprotein classes, can be significantly lowered by the administration of desiccated thyroid. In those studies the effects were evaluated of 10 grains of USP thyroid daily administered over a period of nine to ten weeks and of 3 grains of thyroid daily over a period of three weeks. On the 10-grain regimen, the 11 patients studied showed significant and maintained reduction in the concentration of Standard SfO–12 and Standard Sf 12–20 lipoprotein classes during the nine to ten weeks of thyroid administration. It became of interest to know the minimum dosage of thyroid required to produce and maintain lipoprotein depression. The early experience with 3 grains of USP thyroid daily had shown that an acute response, at least, could be obtained; therefore, the present studies were initiated at this dosage level.

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