T Lymphocytes from Hemophiliacs Proliferate after Exposure to Factor VIII Product
- 31 July 1986
- journal article
- research article
- Published by Wiley in Vox Sanguinis
- Vol. 51 (2) , 92-95
- https://doi.org/10.1111/j.1423-0410.1986.tb00221.x
Abstract
Chronic exposure of hemophiliacs to allogeneic proteins via factor VIII concentrate for control of bleeding could lead to a state of chronic antigen stimulation. Immune function from eight hemophiliacs requiring large amounts of factor VIII concentrate was assessed. It was found that 5 of 8 had a positive blastogenic response to low concentrations of factor VIII in a 7-day thymidine uptake assay. Separation of lymphocyte subpopulations indicated that the reactivity was contained in the T cell-enriched fraction. There was no blast transformation noted secondary to the factor VIII product in 20 controls tested in a 7-day assay nor was there any mitogenic effect of the factor VIII in a 3-day assay. In fact, high concentrations of factor VIII impaired that T lymphocytes from hemophiliacs are antigenically primed to some constituent in the lyophilized factor VIII concentrate.This publication has 10 references indexed in Scilit:
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