Versatile inducible activation system of Akt/PKB signaling pathway in mice
- 6 February 2003
- Vol. 35 (3) , 160-163
- https://doi.org/10.1002/gene.10180
Abstract
Summary: We report a transgenic mouse line in which Akt/protein kinase B (PKB) pathway can be activated in an inducible manner in defined cell types. In this transgenic mouse line, Cre expression allows the expression of a tamoxifen‐activatable form of Akt/PKB in a defined cell type. Subsequent injection of tamoxifen triggers the transient activation of Akt/PKB in mice. Thus, this transgenic line allows the transient activation of Akt/PKB pathway in a predefined cell type. We expect that this transgenic system will provide a unique tool to study the roles of Akt/PKB pathway in mice. genesis 35:160–163, 2003.Keywords
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