Adaptive Response and the Bystander Effect Induced by Radiation in C3H 10T½ Cells in Culture
- 1 August 2001
- journal article
- Published by Radiation Research Society in Radiation Research
- Vol. 156 (2) , 177-180
- https://doi.org/10.1667/0033-7587(2001)156[0177:aratbe]2.0.co;2
Abstract
Sawant, S. G., Randers-Pehrson, G., Metting, N. and Hall, E. J. Adaptive Response and the Bystander Effect Induced by Radiation in C3H 10T½ Cells in Culture. Radiat. Res. 156, 177–180 (2001). This paper discusses two phenomena of importance at low doses that have an impact on the shape of the dose–response relationship. First, there is the bystander effect, the term used to describe the biological effects observed in cells that are not themselves traversed by a charged particle, but are neighbors of cells that are; this exaggerates the effect of small doses of radiation. Second, there is the adaptive response, whereby exposure to a low level of DNA stress renders cells resistant to a subsequent exposure; this reduces the effect of low doses of radiation. The present work was undertaken to assess the relative importance of the adaptive response and the bystander effect induced by radiation in C3H 10T½ cells in culture. When the single-cell microbeam delivered from 1 to 12 α particles through the n...Keywords
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