Intracranial Hemorrhage in Infants

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Abstract
To the Editor: Simmons and his colleagues1 are to be congratulated for their attractive hypothesis that much of the intracranial hemorrhage in infants with respiratory-distress syndrome reflects adverse effects of iatrogenic hypernatremia. Their recommendations must be interpreted with caution, however, unless it can be shown that the two populations (1966–67 and 1970–71) were at equal risk of intracranial hemorrhage except for differences in frequency and extent of hypernatremia.A breakdown of all University of Colorado Medical Center newborn admissions (i.e., inborn plus transferred infants) shows that 327 babies were transferred in 1966–67 whereas only 129 were transferred in 1970–1971. Neonatal . . .

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