Association of Single-Nucleotide Polymorphisms of the Tau Gene With Late-Onset Parkinson Disease
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Open Access
- 14 November 2001
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 286 (18) , 2245-2250
- https://doi.org/10.1001/jama.286.18.2245
Abstract
Parkinson disease (PD) is a progressive neurologic disorder that affects more than 500 000 people in the United States.1 The etiology of PD is complex and likely involves several different environmental and genetic factors. Familial aggregation and sibling risk studies2,3 have supported a genetic component for late-onset, idiopathic PD. Two genes (α-synuclein and parkin) have been identified that lead to very rare mendelian forms of the phenotype.4,5 However, our recent genome screen for linkage in PD produced the first strong evidence suggesting multiple genetic susceptibility loci for the common form of PD.6Keywords
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