Biochemical Pattern in Experimental Exposure of Humans to White Spirit. II. The Effects of Repetitive Exposures

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Abstract
The concentration of P[plasma]-Ig (P-IgG, P-IgA, P-IgM), P-orosomucoid, S[serum]-creatine kinase (S-CK) and S-FSH was investigated in 7 subjects exposed to 100 ppm of the industrial solvent white spirit, 6 h/day for 5 days while 5 subjects were used as unexposed controls. The mean values for S-CK concentration in the exposed group increased significantly with 59 and 76% above the base-line (0 h vlaue) 96 h and 168 h, respectively, after the start of the exposure (P < 0.05), while the mean values for S-FSH concentration decreased significantly to 11 and 9% below the base-line after 24 and 96 h (P < 0.05), respectively. S-CK concentration and S-FSH concentration in the control group remained unchanged. A marked interindividual and intraindividual variance in S-CK concentration and S-FSH concentration was observed. No changes in the concentration of Ig and orosomucoid were observed in both groups during the experiment. The mechanisms for the changes were not known, but solvent induced changes in muscle cell membranes with subsequent enzyme leakage seemed to explain the increase in S-CK concentration; an effect in the hypothalamic FSH releasing hormone may have explained the decrease in S-FSH concentration.