Structure and synthesis of the aryltetralin lignans hypophyllanthin and nirtetralin
- 1 January 1982
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 4,p. 999-1003
- https://doi.org/10.1039/p19820000999
Abstract
Structures previously suggested for hypophyllanthin, the major aryltetralin lignan constituent of Phyllanthus niruri are shown to be incorrect. The structure r-1-(3,4-dimethoxyphenyl)-6-methoxy-t-2,c-3-bismethoxymethyl-7,8-methylenedioxy-1,2,3,4-tetrahydronaphthalene (5) now proposed is confirmed by an unambiguous synthesis. Synthesis of the congener, nirtetralin, is also described.This publication has 0 references indexed in Scilit: