Leukemia and Reticular Neoplasms in the Mouse after Intermittent Irradiation

Publisher Website
Google Scholar
Abstract
A strain mice were exposed to total-body X-irradiation given as 100 r weekly to 3 predetermined totals of 500 r, 1000 r and 1500 r. A 4th group served as controls. The mice were killed when moribund and examined for neoplasms of their reticular tissues. Fourteen percent of control mice developed lymphoid leukemia without enlargement of the thymus. No other neoplasms were common in control animals. The distribution of lymphoid neoplasms in the irradiated animals suggested a complex hormonal control of lymphomagenesis. The sex hormones and a thymic factor appeared the most prominent influences. Myeloid leukemia and localized reticular neoplasms were rarely seen, but their incidence appeared increased by the irradiation.