Intravenous Injection of Fat-Soluble Vitamins and Transfer to Milk of Injected Vitamin

Publisher Website
Google Scholar
Abstract
Milch cows were given (1) intravenous injections of an aqueous vitamin A dispersion, (2) the same dispersion orally, and (3) the same vitamin A dissolved in corn oil. Increased milk vitamin A following the dose was 15 times as great with intravenous injection and 5 times as great with an oral dose of the aqueous dispersion as with an oily solution given orally (oral doses were given through a stomach tube). The maximum transfer took place much earlier with intravenous injection than with oral administration. This is in harmony with the theory of diffusion, since maximum blood levels are reached immediately and are higher following intravenous injections than with oral doses. After repeated injection of the aqueous dispersion into rabbits, gross examination, microscopic survey of vital organ sections, and chemical analysis revealed no pathology.