Toxicity of Gossypol at Antifertility Dosages in Male Rats: Statistical Analysis of Lethal Rates and Body Weight Responses

Publisher Website
Google Scholar
Abstract
The lethal rates and body weight responses of male Wistar rats following oral treatment with gossypol acetic acid (GAA) at dosages of 2.5-30 mg/kg were analyzed by various statistical procedures. Daily treatment with GAA for 10 wk was associated with lethal rates significantly different from placebo groups in both the low dose (2.5, 5.0 and 7.5 mg/kg, P < 0.05) and high dose groups (15, 20 and 30 mg/kg, P < 0.01). The pronounced mean body weight gain observed in placebo groups, was suppressed in the GAA-treated groups at each dose level after 10 wk. This indicates decreased appetite and/or lessened feed intake caused by GAA activity. GAA administration at a dose of 30 mg/kg every other day exerted the same deleterious effects as daily treatment. As derived from the antifertility responses of the GAA treatment groups, it was evident that the toxic activity of GAA was not related to its antifertility efficacy. Evidently GAA has remarkable toxicity at antifertility dosages in rats.

This publication has 15 references indexed in Scilit: