Effect of Hypophysectomy and Adrenalectomy on Enzymes Concerned with Nicotinamide Adenine Dinucleotide Synthesis

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Abstract
The effect of hypophysectomy and adrenalectomy on hepatic nicotinamide mononucleotide pyrophosphorylase, nicotinate mononucleotide pyrophos-phorylase, quinolinate transphosphoribosylase and NAD kinase in the rat has been studied. Nicotlnate mononucleotide pyrophosphorylase and quinollnate transphosphoribosylase activity was not affected by either adrenalectomy or hypophysectomy. Nicotinamide mononucleotide pyrophosphorylase activity was significantly decreased by hypophysectomy and adrenalectomy. NAD kinase activity was decreased by hypophysectomy but was not altered by adrenalectomy. Paired-feeding experiments indicate that dietary restriction does not alter the activities of NMN-pyrophosphorylase or nicotinate mononucleotide pyrophosphorylase. Dietary restriction does, however, appear to duplicate the effects of hypophysectomy on NAD kinase.