Prediction of arenavirus fusion peptides on the basis of computer analysis of envelope protein sequences

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Abstract
Theoretical search and selection criteria for putative fusion peptides of enveloped viruses are proposed. Arena virus fusion peptides are predicted on the basis of computer-assisted analysis of amino acid sequences of arenavirus envelope proteins and elements of their secondary and tertiary structure. Accordingly, two regions of GP2 surface protein from 5 viruses of Arenaviridae family have been detected with properties typical of fusion peptides of other enveloped viruses. One region, named peptide IV, located at the N-terminus of the GP2 protein, is followed by the other region or peptide V, more likely candidate for the arenavirus fusion peptide.