Busulfan kinetics
- 1 July 1983
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 34 (1) , 86-89
- https://doi.org/10.1038/clpt.1983.134
Abstract
Busulfan kinetics were studied in patients with chronic myelocytic leukemia after oral doses of 2, 4 and 6 mg. The plasma concentration-time data could be fitted to a zero-order absorption one-compartment open model. The elimination rate constant averaged 0.27 .+-. 0.05 h-1 (SD). The plasma AUC [area under the concentration-time curve] was linearly related to the dose. The lag time for the start of absorption, the time absorption ends, and the absorption rate constant showed some interindividual variations. About 1% of busulfan is excreted unchanged in urine over 24 h.This publication has 0 references indexed in Scilit: