INABILITY OF VITAMIN-A-DEFICIENCY TO ALTER BENZO(A)PYRENE METABOLISM IN SYRIAN-HAMSTERS
- 1 January 1978
- journal article
- research article
- Vol. 38 (6) , 1497-1501
Abstract
Syrian golden hamsters were placed on a control or vitamin A-deficient diet. When their serum vitamin A content was significantly reduced, i.e., to less than 10% of controls, the hamsters were killed and lung aryl hydrocarbon hydroxylase activity and metabolism of the carcinogen benzo(a)pyrene were determined. The benzo(a)pyrene metabolite profile was similar with control and A-deficient systems, and only few quantitative differences were noted. Addition of .beta.-retinyl acetate to the in vitro incubations did not substantially affect benzo(a)pyrene metabolism.This publication has 2 references indexed in Scilit:
- Nuclear metabolism of benzo(a)pyrene and of (±)-trans-7,8-dihydroxy-7,8,-dihydrobenzo(a)pyreneArchives of Biochemistry and Biophysics, 1977
- Sensitive fluorometric method for tissue tocopherol analysisLipids, 1976