Chalcone carboxylic acids. Potent differentiation inducers of human promyelocytic cells HL-60.

1 January 1985

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 33 (1) , 404-407
https://doi.org/10.1248/cpb.33.404

Abstract

Alkyl-substituted chalcone-4'-carboxylic acids are very potent inducers of differentiation of human promyelocytic cells HL-60. The differentiated cells are morphologically and functionally granulocytes.

Keywords

CHALCONE
ALKYL
FUNCTIONALLY
SUBSTITUTED
CARBOXYLIC ACIDS
MORPHOLOGICALLY
GRANULOCYTES
POTENT DIFFERENTIATION

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