RAPID PRENATAL-DIAGNOSIS OF BETA-THALASSEMIA USING DNA AMPLIFICATION AND NONRADIOACTIVE PROBES
- 1 February 1989
- journal article
- research article
- Vol. 73 (2) , 372-374
Abstract
We used in vitro DNA amplification by the polymerase chain reaction and nonradioactive probes for prenatal diagnosis of .beta. thalassemia in Chinese from the Guangdong province. Exact molecular diagnoses were made in all 20 fetuses studied over a 6-month period. We conclude that this method of prenatal diagnosis for .beta. thalassemia is a viable approach in many parts of the world where this disease is common.This publication has 3 references indexed in Scilit:
- Diagnosis of Sickle Cell Anemia and β-Thalassemia with Enzymatically Amplified DNA and Nonradioactive Allele-Specific Oligonucleotide ProbesNew England Journal of Medicine, 1988
- A SIMPLE APPROACH TO PRENATAL-DIAGNOSIS OF BETA-THALASSEMIA IN A GEOGRAPHIC AREA WHERE MULTIPLE MUTATIONS OCCUR1988
- Molecular basis of ? thalassemia in South ChinaHuman Genetics, 1988