PRELIMINARY STUDY OF A PREGNANOLONE EMULSION (KABI 2213) FOR I.V. INDUCTION OF GENERAL ANAESTHESIA

Open Access

1 March 1992

journal article
research article
Published by Elsevier in British Journal of Anaesthesia

Vol. 68 (3) , 272-276
https://doi.org/10.1093/bja/68.3.272

Abstract

Pregnanolone emulsion was administered i.v. to 13 healthy male volunteers to assess its potential as an agent for i.v. induction of general anaesthesia and to establish a pharmacokinetic profile at two doses. Each subject received 0.5mg kg⁻¹ 0.75mg kg⁻¹ and 1.0 mg kg⁻¹ on successive occasions, the rate of administration being constant for each dose. Pregnanolone emulsion was found to produce smooth and reliable induction of general anaesthesia with cardiorespiratory effects comparable to those of other i. v. induction agents.

Keywords

I.V
PREGNANOLONE EMULSION
INDUCTION OF GENERAL ANAESTHESIA

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