Characterization of two insulin-binding components of rat-liver plasma membranes
- 1 October 1982
- journal article
- research article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 2 (10) , 785-793
- https://doi.org/10.1007/bf01114938
Abstract
We have identified and isolated two forms of insulin receptor from rat-liver plasma membranes. The smaller (Mr = 90k) is a single polypeptide. The same poly-peptide appears to be the insulin-binding site of the largerMr = 280k). Only the larger, multisubunit, receptor shows high-affinity binding of insulin and negative cooperativity in its dissociation kinetics.This publication has 28 references indexed in Scilit:
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