Analysis of Mixtures of Doxycycline and Oxytetracycline in Pharmaceutical Preparations by First Derivative Fluorimetry
- 1 May 1990
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 23 (5) , 863-876
- https://doi.org/10.1080/00032719008052487
Abstract
The utility of first-derivative fluorimetry for the determination of doxycycline and oxytetracycline through the formation of their chelates with aluminium, is discussed. Mixtures of these compounds were determined by first-derivative fluorimetry with linear calibration graphs established between 0.2 and 1.4 μgml−1 for doxycycline and between 0.05 and 0.6 μgml−1 for oxytetracycline. The application of the method to the analysis of these compounds in pharmaceutical preparations is described and a statistical evaluation of the experimental results is reported.Keywords
This publication has 28 references indexed in Scilit:
- Spectrophotometric determination of tetracyclines and cephalosporins with ammonium vanadateTalanta, 1983
- Elucidation of metanephrine to normetanephrine and epinephrine to norepinephrine ratios by fluorescence derivative spectroscopyAnalytical Chemistry, 1982
- Quantitative determination of tryptophanyl and tyrosyl residues of proteins by second-derivative fluorescence spectroscopyAnalytical Biochemistry, 1982
- The applicability of the second-derivative method to room-temperature phosphorescence analysisAnalytica Chimica Acta, 1979
- Derivative and wavelength modulation spectrometryAnalytical Chemistry, 1979
- Numerical error analysis of derivative spectrometry for the quantitative analysis of mixturesAnalytical Chemistry, 1976
- Derivative luminescence spectrometryAnalytical Chemistry, 1974
- Tetracyclines II Separation and determination by column chromatographyJournal of Pharmaceutical Sciences, 1967
- The spectrophotometric assay for chlortetracycline1 HCl and tetracycline1 HCl in pharmaceuticals**Lederle Laboratories Division, American Cyanamid Co., Pearl River, N. Y.1Trademark of Lederle Laboratories Division, American Cyanamid Co., for chlortetracycline is Aureomycin and for tetracycline is Achromycin.Journal of the American Pharmaceutical Association (Scientific ed.), 1959
- The chemical assay of aureomycinJournal of the American Pharmaceutical Association (Scientific ed.), 1949