Hepatic Abnormalities in Alcoholics with Delirium Tremens

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Abstract
Aspiration biopsy of the liver was performed in 66 alcoholic patients with delirium tremens. Histological study revealed a normal liver structure in 19, focal inflammation in 4, fatty infiltration in 20, and portal cirrhosis in 23 patients. Clinical and biochemical studies did not provide a clue to the encountered histology. Hepatic abnormalities were correlated with previous dietary habits. A diet deficient in lipotropic substances was associated with fatty infiltration and eventually led to fibrosis and portal cirrhosis. The degree of alcoholism and severity of cerebral symptoms could not be correlated with hepatic changes. Serial observation showed deterioration in clinical, biochemical, and histological findings in patients returning to alcoholism and poor dietary habits. Rehabilitation of the alcoholic patient prevented progressive liver injury.