ACCELERATED PROGRESSION OF DIABETIC NEPHROPATHY IN THE SPONTANEOUSLY HYPERTENSIVE STREPTOZOTOCIN DIABETIC RAT

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Abstract
1. Streptozotocin (STZ)‐diabetes was induced in spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats with their litter mates serving as controls. The animals were studied for 6 months and blood pressure, weight, urinary and serum glucose, creatinine clearance, total proteinuria and albuminuria were measured monthly. 2. With induction of diabetes, there was a significant rise in creatinine clearance in the hypertensive diabetic animals (SHR‐STZ). SHR‐STZ (n= 6) developed higher levels of total proteinuria than WKY‐STZ (n= 5) although the rise from basal levels was only apparent after 20 weeks of diabetes. All SHR‐STZ developed albustix positive proteinuria after 6 months of diabetes. 3. In the first 12 weeks after onset of diabetes, albuminuria increased to a greater degree in SHR‐STZ than in WKY‐STZ. This occurred before there was a detectable rise in total proteinuria. 4. The SHR‐STZ model of genetic hypertension and diabetes may be suitable for the evaluation of antihypertensive therapy in human diabetic renal disease.