An extended physiological pharmacokinetic model of methadone disposition in the rat: Validation and sensitivity analysis

1 April 1988

journal article
research article
Published by Springer Nature in Journal of Pharmacokinetics and Biopharmaceutics

Vol. 16 (2) , 183-201
https://doi.org/10.1007/bf01062260

Abstract

An extended physiological model of methadone disposition in the rat was constructed and evaluated in various tests of model validity. A separate circulation model of the fetus was included due to the large tissue concentration differences obtained after a constant rate infusion but also to propose the use of this type of model for optimization of toxicological tests. Simulations were performed with the animal model and scaled-up models of humans to elucidate the determinants of methadone dispostion. The rationale of the use of an extended model for methadone was also discussed.

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