Cell Culture Studies in 19 Cases of Refractory Anaemia: Comparison of Clinical Data with in Vivo Erythrokinetic Studies

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Abstract
Cases (19) of chronic refractory anemia underwent simultaneous in vivo erythrokinetic study and in vitro bone marrow culture and were followed up clinically for at least 2 yr. Good correlation was found between erythrokinetic data (simultaneous quantitative and qualitative disorders of erythroblastic proliferation in preleukemic states, pure qualitative disorders in primary sideroblastic anemia) and results of culture of granulocyte precursors in bone marrow (small number of colonies, reduced size of colonies in preleukemic states; normal number and growth in nonmalignant refractory anemia). Both examinations are of practical interest in clinical hematology and apparently make it possible to foresee malignant evolution of some refractory anemias.

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