Abstract
1. A series of experiments with variously treated RBC stroma injected intra-peritoneally into mice clearly demonstrates that an eosinophile-stimulating substance previously noted is not a lipid. 2. The experiments further establish that the substance is either a protein or a protein-carbohydrate compound. 3. The possibility is raised that the physical state of material (gel or insoluble suspension) may determine the eosinophilic response.

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