Aromatase activity in monolayer cell cultures of human endometrium
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Gynecological Endocrinology
- Vol. 1 (4) , 339-343
- https://doi.org/10.3109/09513598709082706
Abstract
Monolayer cell cultures of proliferative human endometrial stramal cells were incubated with 100 nCi 3H-androstenedione or 100 nCi 3H-testosterone for 15 hours. After termination of the incubations 16% of the recovered radioactivity was identified as estronc by thin layer chromatography and subsequent recristillization. 3H-testosterone was almost quantitatively converted to -3H-androstenedione. 3H-dihydro testosterone remained unmetabolized. These findings indicate a highly active 17β-ol-dehvdrogenase and a high aromatizing capacity of human endometrial cells.Keywords
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