Pharmaceutical Evaluation of Hollow Type Suppository. I. Brilliant Blue FCF Release Characteristics of Oleagenous Hollow Type Suppository

Publisher Website
Google Scholar
Abstract
A new type of suppository with a hollow cavity into which drugs, in the form of powder, liquid or solid, could be placed was constructed. The advantage of the use of this hollow-type suppository is that interactions between drug and the oily-base suppository materials can be essentially eliminated. Brilliant blue FCF (BB) was selected as a model drug since the rate of dissolution could be observed visually. New type suppositories and conventional type suppositories were constructed with 4 different oily-base materials. The dissolution rates of BB in vitro from the new-type could then be compared with those of conventional-type suppositories made from the same base material. With conventional construction, the rates differed considerably depending on the base material. With the new type no difference was found between the 4 materials tested. Similar results were obtained if the BB was added to the suppository as a fine powder, aqueous solution or macrogol mixture. Plasma concentration of BB were measured in rabbits after the rectal administration of the suppositories. The hollow-type suppositories were evidently less influenced by the type of base material than were the conventional types.

This publication has 2 references indexed in Scilit: