The Gastric Mucosa in Stomachs with Polyps: Morphologic and Dynamic Evaluation

Publisher Website
Google Scholar
Abstract
Biopsy specimens from the antral and body mucosa of 183 patients with gastric polyps (adenoma, 4; hyperplastic polyp (HP), 52; foveolar hyperplasia (FH), 49; and inflammatory polyp (IP), 78 cases) have been examined. The prevalence of gastritis in the series was compared with that in 183 age- and sex-matched controls. The dynamics (progression) of gastritis was evaluated by means of an age-adjusted gastritic score. In the HP and FH groups the prevalence and progression of body gastritis were significantly higher and more rapid (p < 0.001) while the prevalence of antral gastritis was lower (p < 0.05) and its progression less rapid (p < 0.001) than in controls. It is concluded that the pernicious anaemia type of gastritis (A-type gastritis) is closely related to gastric polyps of hyperplastic origin. The progression of this gastritis type seemed to increase in the order IP, FH, and HP. In addition, we observed an increase in the prevalence of intestinal metaplasia (p < 0.001) and marked epithelial dysplasia (0.1 > p > 0.05; chi-square = 3.75) in stomachs with polyps as compared with in controls.