Authors report on four patients with clinically typical multiple sclerosis with onset in childhood up to the tenth year of life. Though the onset of the disease in childhood is unusual, a pediatrician confronted with a child showing evidence of scattered neurologic deficits that remit should consider the possibility of multiple sclerosis. The disease does not appear to differ clinically from the disease as observed in adults, in respect to mode of onset, symptoms, and physical findings. Even in childhood the chronic non remitting course does occur.