Synthesis and Properties of 6A-Amino-6A-deoxy-α and β-cyclodextrin
- 1 January 1993
- journal article
- research article
- Published by CSIRO Publishing in Australian Journal of Chemistry
- Vol. 46 (6) , 953-958
- https://doi.org/10.1071/ch9930953
Abstract
The monotosylates obtained by treatment of α- and β- cyclodextrin with p- methylbenzenesulfonyl chloride reacted with ammonia to give the title compounds. These amines are of unusually low basicity , with pKa values of 8.70 and 8.72, respectively. In water at 25°, the hydrochloride salt of the amine derived from β- cyclodextrin is approximately 40 times more soluble than β-cyclodextrin and, through complexation, the salt increases the solubility of Nabumetone over 800 times.Keywords
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