The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins.

  • 1 September 1995
    • journal article
    • Vol. 6  (9) , 1193-8
Abstract
The BTB/POZ domain defines a newly characterized protein-protein interaction interface. It is highly conserved throughout metazoan evolution and generally found at the NH2 terminus of either actin-binding or, more commonly, nuclear DNA-binding proteins. By mediating protein binding in large aggregates, the BTB/POZ domain serves to organize higher order macromolecular complexes involved in ring canal formation or chromatin folding.

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