Hypokalaemic alkalosis and hyperplasia of the juxtaglomerular apparatus without hypertension or oedema.

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Abstract
A disorder characterized by hypokalemia, evidence of hyperaldo-steronism, increased plasma renin activity, increased granularity of the juxtaglomerular apparatus, glomerular abnormalities, normal blood pressure, and decreased pressor response to exogenous angiotensin is described in a non-edematous 18-year-old prepubertal Negro youth and is compared with a similar condition described in 3 other patients. The pathogenesis of the syndrome is discussed and evidence for an abnormality of extracellular fluid volume control is presented.