NEURO-PHARMACOLOGICAL PROFILE OF MD-790501, A NEW BENZAMIDE DERIVATIVE

  • 1 January 1983
    • journal article
    • research article
    • Vol. 264  (2) , 232-256
Abstract
In several classical screening procedures in different species [mice, rats, dogs and Macaca mulatta] MD 790501: exo-2,3-dimethoxy-N-[8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]benzamide hydrochloride, had potent neuroleptic properties. The doses effective in the tests for neuroleptic activity were similar to or lower than those for haloperidol and clearly lower than those for bromopride, chlorpromazine, sulpiride, sultopride and thioridazine. Compared with the reference compounds tested, MD 790501 showed sedative, cataleptic and dyskinetic effects at doses relatively higher than those effective in tests for neuroleptic activity. MD 790501 possessed no noradrenolytic, anticholinergic, proconvulsant or anxiolytic activity. Its acute toxicity was in the same dose range as that of reference neuroleptics.