Recurrent Migraine and Intravenous Immune Globulin Therapy

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Abstract
Headache during or after intravenous immune globulin infusion is a common side effect of this increasingly frequent treatment. Headache usually occurs with initial infusions, particularly when they are administered at fast rates, but may recur even with slower subsequent infusions. Frequently, these headaches are palliated with acetaminophen and diphenhydramine. Aseptic meningitis has been associated with recurrent intravenous-immune globulin-associated headaches1-3. We report on a patient in whom migraine developed after his first intravenous immune globulin treatment. Migraine recurred after the second treatment, and propranolol prevented subsequent treatment-associated headaches.