In vivo Effects of Defibrotide on Platelet c-AMP and Blood Prostanoid Levels

1 January 1986

journal article
Published by S. Karger AG in Pathophysiology of Haemostasis and Thrombosis

Vol. 16 (Suppl. 1) , 31-35
https://doi.org/10.1159/000215337

Abstract

Patients were treated with defibrotide (3 × 200 mg/day) for 7 days. Plasma PGI2 and TXB2 levels were measured by RIA using EDTA-aspisol as anticoagulant and cyclooxygenase inhibitor. Isolated platelet c-AMP levels were also determined by RIA, using EDTA-dipyridamole as anticoagulant and phosphodiesterase inhibitor. Blood PGI2 levels were found to increase significantly upon treatment while the increase in TXB2 levels was not significant. Blood PGI2/TXB2 ratio increased 51%, 30 min after intravenous injection and it remained 28% higher during therapy than the predrug blood level. Significantly higher platelet c-AMP levels were also obtained after the injection of drug (0.02 < p < 0.05).

Keywords

This publication has 0 references indexed in Scilit: