Ventilatory Depression Related to Plasma Fentanyl Concentrations during and after Anesthesia in Humans
- 1 November 1983
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Anesthesia & Analgesia
- Vol. 62 (11) , 966???974-74
- https://doi.org/10.1213/00000539-198311000-00002
Abstract
Twenty-four patients were allocated randomly into four groups for the study of the pharmacokinetics of, and effects on postoperative ventilation of, two doses of fentanyl (10 μg/kg or 25 μg/kg) administered at the start of general anesthesia in which ventilation was controlled at a fixed volume, but arterial PCO2 was adjusted to a range of either 38–42 torr, or 20–25 torr. During the first 2 hr after anesthesia, ventilatory depression (CO2 responsiveness decreased to 48 torr) occurred only in patients who had received 25 μg/kg fentanyl, and was more marked in patients who were hyperventilated to a low PACO2 during anesthesia. Plasma fentanyl concentrations associated with 50% depression of CO2 responsiveness were in the range 1.5–3.0 ng/ml, the lower values found in patients hyperventilated to a low PACO2. Whole-body clearance of fentanyl was significantly decreased by hypocapnic hyperventilation.Keywords
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