DETECTION OF DIFFERENT DNA STEM CELL LINES IN A CASE OF HUMAN BLADDER CARCINOMA

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Abstract
An unusual case of bladder carcinoma is presented. The cystectomy specimen contained 1 large tumor with the histological picture of a poorly-moderately well-differentiated squamous cell carcinoma and another small tumor with poorly-differentiated transitional cell carcinoma. Widespread areas of carcinoma in situ were seen. Random biopsies from the bladder and from the tumors were independently examined, histopathologically and by flow-cytofluorometric DNA-analyses. The degree of ploidy was quite different between the 2 tumors. In areas of carcinoma in situ different aneuploid cell lines were indicated. Altogether 5 different aneuploid cell lines were found. There was a good correlation between the histopathological assessments and the DNA measurements: carcinoma in situ corresponding to aneuploidy and various degrees of atypia corresponding to diploidy. In tumor metastases from several organs, only 1 aneuploid cell line was found. This cell line did not correspond to those found in the tumors.