The effects of verapamil on cerebrospinal fluid pressure in surgical patients

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Abstract
The effects of verapamil upon cerebrospinal fluid pressure (CSFP) were studied in twenty surgical patients without intracranial pathology who were divided into two groups of ten patients each: verapamil 0.075 mg·kg−1 was given in group 1 and 0.15 mg·kg−1 was given in group 2. A spinal needle was inserted into the subarachnoid space to permit continuous measurement of CSFP. Intravenous verapamil as a bolus produced a statistically significant increase in CSFP: from 6.0±3.5 (mean±SD) to 10.5±4.3 mmHg in group 1 (PP−1 ) has no neurological side effects in patients without intracranial hypertension. However, it must be emphasized that verapamil may increase CSFP to undesirable levels and should be avoided in patients with compromised intracranial compliance.