Blood Pressure in Chronic Renal Failure

Abstract
Control of hypertension is important in the management of chronic renal failure. Data presented here support the view that hypertension in chronic renal failure develops because many patients must have elevated blood pressure in order to excrete the amounts of sodium usually ingested. The data indicate that there is a wide spectrum with respect to the excretion of sodium by the diseased kidney and those patients who excrete the lowest amount of sodium have the greatest difficulty with control of blood pressure. Attempts to lower blood pressure by restricting sodium in the diet often cause such a marked reduction in sodium excretion that the patient has to reduce dietary sodium intake to an intolerably low level in order to stay in balance. In such patients preliminary experience indicates that furosemide can increase sodium excretion sufficiently to maintain sodium balance on an acceptable diet without an increase in blood pressure.

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