Über die Bildung von Wasserstoffperoxyd bei der Hemmung der Glykolyse von Ascites-Tumorzellen durch Phenanthrenchinon
Open Access
- 1 February 1961
- journal article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung B
- Vol. 16 (2) , 120-126
- https://doi.org/10.1515/znb-1961-0209
Abstract
Under aerobic conditions hydrogenperoxide is formed in a glycolyzing suspension of Ehrlich-Ascites tumor cells after incubation with phenanthraquinone(9.10). Not glycolyzing tumor cells and also a kidney cell suspension produce very little hydrogenperoxide only. In glycolyzing tumor cells phenanthraquinone(9.10) is reduced rapidly to the corresponding hydroquinone. During the autoxidation of the hydroquinone hydrogenperoxide is formed. A great stimulation of O2-uptake is related with the autoxidation reaction. This stimulation also appears after blocking the respiratory chain by cyanide. The inhibition of tumor cell glycolysis is caused by an inhibition of glycerinaldehydphosphatdehydrogenase and a decrease of the DPN level.Keywords
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