Large invasive chromophobe adenoma with well‐preserved pituitary gland

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Abstract
A 40-year-old man suffered from a huge chromophobe adenoma which invaded the sphenoid and right temporal bones, the sphenoid and ethmoid sinuses, and the right cavernous sinus with subsequent proptosis and severe pain in the right eye. An unusual feature of this case was the good preservation of the pituitary gland, even though it was surrounded by tumor tissue and the bony sella was destroyed. In accordance with the preservation of the pituitary gland, there was no atrophy of the adrenals, thyroid, or the gonads, and clinical signs of hypopituitarism were absent. It is postulated that the tumor originated from ectopic pituitary tissue either from the body of the sphenoid bone or possibly from the supradiaphragmatic portion of the pituitary stalk.

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