The Natural History of Idiopathic Hypoglycemia of Infancy and Its Relation to Diabetes Mellitus

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Abstract
A SPECIFIC etiology has not been determined in the majority of infants and children with symptomatic spontaneous hypoglycemia.1 This idiopathic hypoglycemia typically has its onset before two years of age, presenting as a seizure disorder. Known endocrine or enzymatic abnormalities cannot be demonstrated, and there are no characteristic physical signs. The hypoglycemia may be continuous or intermittent, can vary greatly in severity from time to time and under-goes spontaneous amelioration over a period of months or years.The present study was undertaken to define a 2ssible relation between infantile idiopathic spontaneous hypoglycemia and other familial abnormalities in carbohydrate metabolism. The . . .