THROMBOCYTOPENIA IN THE EXPERIMENTAL PRODUCTION OF HEMORRHAGIC DEATH BY MULTIPLE FACTORS

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Abstract
Three experimental conditions were established in rats either singly or in combination: (a) thrombocytopenia by the intraperitoneal administration of a single dose of radioactive phosphorus, 4 μc/g of body weight, (b) prothrombopenia by the oral administration of dicumarol, 2 mg/100 g of body weight per day for 7 days, (c) stress by the intraperitoneal administration of a single dose of 10% NaCl, 2.5 ml/100 g of body weight. The response to the treatment was measured by the level of circulating platelets and the prothrombin time. The cause of death was assessed by gross and, occasionally, histological examination of the organs of the animals that had died within 15 days of the injection of the radioactive phosphorus.The percentage mortality from spontaneous hemorrhage when thrombocytopenia was combined with either hypocoagulability or stress was very much greater than the mortality resulting from a single treatment, or from a simple additive effect (P «0.01). Mortality due to hemorrhage was thrombocytopenia, 20%; P32 without thrombocytopenia, 0% (also together with dicumarol and with stress); dicumarol, 16%; stress, 0%; thrombocytopenia and dicumarol, 81%; thrombocytopenia and stress, 67%; controls, 0%. These results provide additional support for the hypothesis of spontaneous hemorrhage being caused by multiple factors acting simultaneously.

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