Early Changes in Intracranial Pressure During Haemofiltration Treatment in Patients with Grade 4 Hepatic Encephalopathy and Acute Oliguric Renal Failure

1 January 1990

journal article
research article
Published by Oxford University Press (OUP) in Nephrology Dialysis Transplantation

Vol. 5 (3) , 192-198
https://doi.org/10.1093/ndt/5.3.192

Abstract

We measured the intracranial pressure (ICP), using a subdural catheter in nine patients admitted with grade 4 hepatic encephalopathy due to fulminant hepatic failure complicated by oliguric renal failure. Six patients received daily machine haemofiltration and four patients were treated with continuous arteriovenous haemofiltration (CAVHF). The mean ICP increased during the first hour of machine haemofiltration from 9 ± 1.4 mmHg to 13 ± 1.8 mmHg (PPP<0.05), whereas there was no corresponding change in the CAVHF group. This suggests that CAVHF is to be preferred for the treatment of acute renal failure in such patients who are at considerable risk of developing cerebral oedema.

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