OBSERVATIONS ON THE OESTROGENIC POTENCY OF STILBOESTROL IN THE GUINEA-PIG

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Abstract
Included in the uterine changes which occur in the guinea-pig during normal oestrus is a relative hyperaemia at the antimesometrial border of the bicornate uterus [Bacsich & Wyburn, 1940], and as a similar vascular response has been induced in spayed animals by treatment with oestradiol monobenzoate [Bacsich & Wyburn, 1941] it can be considered as a characteristic of oestrogenic activity. In this work it was also shown that, while vaginal opening, cornification, increase in uterine weight, and all the so far recognized histological features of a typical heat response of the uterus can be elicited in practically 100% of spayed guinea-pigs by a comparatively simple administration of oestradiol monobenzoate, for the successful display of the cyclic vascular change of the uterus with any reasonable certainty, a more specialized treatment, including preliminary priming with small doses, is necessary. Moreover, it was demonstrated that the antimesometrial hyperaemia is an oestrogenic response of

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