A Mild, Convenient Preparation ofN,N-Disubstituted Thioformamides From Secondary Amines
- 1 January 1986
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1986 (06) , 482-484
- https://doi.org/10.1055/s-1986-31681
Abstract
A number of N,N-disubstituted thioformamides can be conveniently prepared in good yield by heating the corresponding secondary amine at about 110°C with commercially available dimethylthioformamide. The reaction is sensitive to steric and electronic factors as evidenced by the failure of N-methylcyclohexanamine and N-methylbenzeneamine to react. Solid thioformamides often crystallize directly from the reaction in analytically pure form.Keywords
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