Antigen Recognition: The Specificity of an Isolated T Lymphocyte Population
Open Access
- 1 February 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 118 (2) , 544-550
- https://doi.org/10.4049/jimmunol.118.2.544
Abstract
Guinea pig lymph node lymphocytes were separated into T and B cell fractions on immunoabsorbent columns. Separated cells were functionally distinct: T cells proliferated in response to ConA, PHA, soluble and alloantigen, whereas anti-Ig reagents only stimulated B cells. The in vitro proliferative response of guinea pig lymph node T lymphocytes was then shown to be highly discriminating when elicited by a series of structurally similar synthetic DNP-oligolysine antigens. Proliferation was always most extensive in response to the homologous, immunizing antigen, and less intense to cross-reacting DNP-oligolysines. Specificity of proliferation was maintained in the absence of both B lymphocytes and antibody secreting cells, suggesting that T cell recognition is not “acquired” from B cells or secreted antibody, but is a property inherent to the T cell.This publication has 3 references indexed in Scilit:
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- Immunogenicity of a Series of α,N-DNP-L-Lysines*Biochemistry, 1965
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