Surface Modification of Polycarbonate with Synthetic Polyelectrolyte-Anticoagulant Activity
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Biomaterials, Medical Devices, and Artificial Organs
- Vol. 12 (3-4) , 215-233
- https://doi.org/10.3109/10731198409118833
Abstract
Natural rubber with C = C bonds had been modified by reaction with chlorosulfonyl isocyanate (CSI) and 70% of the products were obtained, which yielded poly-electrolyte on treatment with NaOH, having sulfamate and carboxylate groups. The polyelectrolyte showed anticoagulant activity. This might be due to the presence of both sulfamate and carboxylate groups arranged in a steric manner in the molecule as that of Heparin. Surface energy parameters, platelet adhesion and plasma recalcification time were investigated. Possible comparison with heparin had been demonstrated.This publication has 13 references indexed in Scilit:
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