Amyloid Aβ40 CSF concentrations correlate to frontal lobe atrophy in frontotemporal dementia

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Abstract
We wanted to further study amyloid Aβ protein alterations in non-AD neurodegenerative diseases. Cerebrospinal fluid concentrations of the amyloid Aβ protein with 40 (Aβ40) and 42 (Aβ42) amino acid residues were measured in eleven patients with frontotemporal dementia (FTD). Aβ40 and Aβ42 concentrations were related to the degree of frontal lobe atrophy as assessed with MRI volumetry. Aβ40 concentrations showed a statistically significant linear correlation with degree of frontal lobe atrophy (r = −0.77, p <0.02). Similar results have not been found in previous studies of CSF Aβ40 concentrations and atrophy in patients with AD which suggest that the role of Aβ40 differs between the pathological processes of FTD and AD.

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